MassARRAY Reagents

Predesigned and prevalidated panels

1) Liquid Biopsy Panels

• UltraSEEK Colon Panel (> 100 variants across BRAF, EGFR, KRAS, NRAS and PIK3CA genes)
• UltraSEEK Lung Panel (> 70 variants across BRAF, EGFR, ERBB2, KRAS and PIK3CA genes)
• UltraSEEK Melanoma Panel (> 55 variants from 13 genes including BRAF, KIT and NRAS)
• UltraSEEK EGFR Panel (6 variants, incl. T790M, C797S, E746_A750del and L858)
• Ultrasensitive – indentify variants at as low as 0.1% variant allele frequency
• Samples types: CTCs, ctDNA, cfDNA

2) High Sensitivity Solid Tumor Panels

• iPLEX HS Colon Panel (> 80 variants across BRAF, EGFR, KRAS, NRAS and PIK3CA genes)
• iPLEX HS Lung Panel (70 variants across BRAF, EGFR, ERBB2, KRAS, and PIK3CA genes)
• iPLEX HS Melanoma Panel (> 90 variants from BRAF, KIT, NRAS, TERT genes)
• Highly sensitive detection of somatic mutations as low as 1% allele frequency
• Samples types: formalin-fixed tissue, fine needle aspirates, core needle biopsies, smears

3) Other Solid Tumor Panels

• ClearSEEK PIK3CA Panel (20 variants of PIK3CA gene in breast cancer samples)
• LungFUSION Panel  (fusion detection of NSCLC in ALK, RET, and ROS1 genes)
• OncoFOCUS Panel (> 200 variants across BRAF, EGFR, KIT, KRAS and NRAS genes)

4) Pharmacogenetic Panels

• Simultaneous testing of key pharmacogenetic SNPs, INDELs, and CNVs
• VeriDose CORE Panel
  • 68 SNPs/INDELs across 20 genes, plus 5 CNVs targets in CYP2D6
  • Designed even for low quality DNA or challenging samples
• VeriDose CYP2D6 CNV Panel
  • Provides accurate detection of CYP2D6 hybrid alleles
  • 22 targets in 7 regions of the CYP2D6 gene
• VeriDose DPYD Panel
  • Analysis of 9 DPYD gene variants connected with drug toxicity

5) Hereditary Genetics

• CFTR Panel - targeted Cystic Fibrosis Mutation Analysis
• Detects 74 most common variants of the CFTR gene, including ACMG and ACOG recommended mutations

 6) Blood Typing Panel

• Hemo ID DQS Panel
• Extended antigen typing of erythrocytes, platelets, and neutrophils
• 42 antigens in 12 blood group systems and 3 beta globin markers
• New or rare donors identification

7) Sample Integrity

• iPLEX Pro Sample ID Panel (44 SNPs and 3 gender markers)
• iPLEX Pro Exome QC Panel (21 SNPs and 3 gender markers, exonic regions) 
• Unique genetic fingerprint for sample identification
• SNP coverage desiged for high quality sample comparisons

8) Chimerism Testing

• Chimeric ID Panel
• For Bone Marrow Engraftment Monitoring
• 92 independent SNPs with high minor allele frequency

9) Methylation

• MassCLEAVE chemistry
• Methylation profiling following the base-specific cleavage on bisulfite-converted DNA
• Detection of down to 5% of differences between methylated and non-methylated DNA