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MassARRAY System

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Home > Gene Editing and Analysis > Gene Analysis > MassARRAY System
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MassARRAY System

Agena Bioscience GmbH

Tool for routine genetic testing and highly sensitive mutation detection

MassARRAY System
Agena Bioscience GmbH

The MassARRAY System is a benchtop MALDI-TOF mass spectrometer that provides sensitive, accurate, and rapid analysis of nucleic acid samples. With throughput capacity to meet the needs of any testing volume, rapid results, and the ability to cost-effectively target hundreds of genetic mutations. System is a complete genomic solution for molecular laboratories.

 

Application

  • Somatic Mutation Profiling
  • Ultrasensitive Detection
  • Sample Identification and Qualification
  • Pharmacogenetics and Inherited Disease
  • Testing Rare Blood Donor Identification
  • Agricultural Genomics

 

System consists of

  • Optimized reagents 
  • SpectroCHIP Array
  • Chip prep module (96 or 384 format)
  • MassARRAY Analyzer 4
  • Application Software

 

Main features

  • Nucleic acid detection by mass spectrometry enables readout by molecular mass
  • Highly accurate alternative to fluorescent-based methods
  • A system set up for 96- and/or 384-well format of samples and assay throughput
  • Efficient Workflow Obtain results in a single day with limited hands-on time
  • A new Chip prep module provides post-PCR automation
  • Direct detection of short amplicons enables compatibility with all nucleic acid sample types
  • Ideal for targeted genetic analysis including
    • SNP genotyping
    • DNA methylation analysis
    • copy number quantification
    • somatic mutation analysis

 

 

Optimized reagents

  • Simple PCR-based iPLEX, UltraSEEK or MassCLEAVE chemistries
  • Compatible with a broad range of nucleic acid biomarkers
  • Suitable for standard germline genotypes to rare somatic variants
  • Efficiently multiplex variants, including SNPs, indels, somatic mutations and CNV’s in the same reaction
  • Suitable for degraded or low quality samples from FFPE, FNA, or plasma 
  • Minimizing DNA sample input
  • MassCLEAVE chemistries are for quantification of methylation changes with limit of detection 5%

 

SpectroCHIP Arrays

  • Ability to automatically process up to two multiplexed 96-, or 384-pad per run
  • Chip prep module minimizes hands on time
  • Reduces the risk of contamination associated with manual handling

 

MassARRAY Analyzer 4 / MassARRAY Dx Analyzer 4

  • Multiplexed analysis of up to hundreds of clinically relevant mutations in a single workflow
  • Powered by sensitive and accurate mass-based detection
  • Maximizes laboratory resources with rapid turnaround time
  • Mature and well-proven MALDI-TOF technology provides high-quality data
  • MassARRAY Dx - CE-IVD marked genetic analysis system
  • MassARRAY Dx provides clinically actionable mutation reports

 

MassARRAY software

  • Flexible and robust tools for the creation and analysis of new test methods
  • Provides interactive visualization of the data for results management and reporting
  • Online design tools enable you to design custom assays

 

 

The MassARRAY process enables sample-to-answer testing with minimal hands-on time in a single eight-hour work shift. Beginning with extracted DNA, multiplexed PCR reactions are followed by extension reactions; analyte is then dispensed onto a SpectroCHIP Array for detection on the MassARRAY Analyzer 4. 

 

Predesigned and prevalidated panels

1) Liquid Biopsy Panels

  • UltraSEEK Colon Panel (over 100 variants across BRAF, EGFR, KRAS, NRAS and PIK3CA genes)
  • UltraSEEK Lung Panel (over 70 variants across BRAF, EGFR, ERBB2, KRAS and PIK3CA genes)
  • UltraSEEK Melanoma Panel (more than 55 variants across 13 genes including BRAF, KIT and NRAS)
  • UltraSEEK EGFR Panel (detection of 6 variants, incl. T790M, C797S, E746_A750del and L858)
  • Ultrasensitive - Indentify variants at as low as 0.1% variant allele frequency
  • For use with CTCs, ctDNA, cfDNA

 

2) High Sensitivity Solid Tumor Panels

  • iPLEX HS Colon Panel (80 variants across BRAF, EGFR, KRAS, NRAS and PIK3CA genes)
  • iPLEX HS Lung Panel (70 variants across BRAF, EGFR, ERBB2, KRAS, and PIK3CA genes)
  • iPLEX HS Melanoma Panel (over 90 variants from BRAF, KIT, NRAS, TERT genes)
  • Highly sensitive detection of somatic mutations as low as 1% allele frequency
  • From samples including formalin-fixed tissue, fine needle aspirates, core needle biopsies, smears

 

3) Other Solid Tumor Panels

  • LungFUSION Panel  (fusion detection of NSCLC across ALK, RET, and ROS1)
  • OncoFOCUS Panel (detection of over 200 variants across BRAF, EGFR, KIT, KRAS and NRAS)

 

4) Pharmacogenetic Panels

  • Simultaneous testing of key pharmacogenetic SNPs, INDELs, and CNVs in a single reaction
  • 96- and 384-well formats offer the flexibility to generate results from 10s to 1000s of samples a day
  • VeriDose CYP2D6 CNV Panel
    • Provides accurate detection of CYP2D6 hybrid alleles
    • Interrogates 22 points in 7 regions of across the CYP2D6 gene
    • This panel can be combined with genotyping panels using the same workflow
  • VeriDose CORE Panel
    • Targets the most relevant variants in 20 principal genes implicated in drug metabolism pathways
    • Interrogates 68 SNPs/INDELs across 20 genes, plus 5 CNVs targets in CYP2D6
    • Designed to be tolerant to low quality DNA, suitable for challenging samples 

 

5) Hereditary Genetics

  • CFTR Panel - targeted Cystic Fibrosis Mutation Analysis
  • Cost-Effective Solution to detect 74 of the most common variants of the CFTR gene
  • 23 mutations recommended by ACMG and ACOG
  • 49 variants with known CFTR relevance and allele frequency >0.1%

 

6) Blood Typing Panel

  • Hemo ID DQS Panel
  • Ready-to-use genotyping assays for extended antigen typing of erythrocytes, platelets, and neutrophils
  • 37 assays in 2 multiplexed wells
  • 42 antigens in 12 blood group systems and 3 beta globin markers
  • identify rare donors

 

7) Sample Integrity

  • iPLEX Pro Sample ID Panel (44 SNPs and 3 gender markers generate unique genetic fingerprint)
  • iPLEX Pro Exome QC Panel (targets exonic regions, 21 SNPs and 3 gender markers) 
  • Provides a highly accurate, rapid method for identification and quantification of samples
  • Provides the ideal SNP coverage for accurate and comprehensive sample comparisons
  • All Sample ID Panels are available in 96- and 384-well formats

 

8) Chimerism Testing

  • Chimeric ID Panel
  • For Bone Marrow Engraftment Monitoring
  • 92 independent SNPs with high minor allele frequency
  • Automated results reporting (software available)
  • Reduces the time and money required to determine composition of a DNA sample

 

9) SARS-CoV-2

  • accurate, high-throughput, and low-cost detection of SARS-CoV-2 and influenza
  • MassARRAY SARS-CoV-2 Variant Panel (RUO)
    • Detects 36 unique mutations and differentiates 15 key SARS-CoV-2 variants
    • Identify the India, UK, South Africa, Brazil, Mink, New York, Florida, California etc. variants
  • MassARRAY SARS-CoV-2/Flu Panel (RUO)
    • Dual SARS-CoV-2 targets
    • Pan-assay design for influenza A subtypes (including H1N1 and H3N2) and influenza B lineages
  • MassARRAY SARS-CoV-2 Panel (CE-IVD in Europe)
    • Five SARS-CoV-2 assays multiplexed
    • Targeting the nucleocapsid (N) gene and ORF1ab region

 

 

Documents and resources

For more information visit producer's website.

MassARRAY System Brochure

Pharmacogenetics Solutions Brochure

Colon Panels Brochure

Lung Panels Brochure

Melanoma Panels Brochure

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